Description of the Disorder
Duchenne muscular dystrophy is a genetic disorder that is characterized by progressive muscle degeneration and weakness. It is caused by a mutation of the DMD gene that can be inherited through transmission of an X-linked recessive gene. DMD codes for the muscle protein, dystrophin. As a result, people who are affected with this disorder are not able to make this protein in their muscles, causing them to become weak and not function properly (NHGRI, 2014). This disorder moves quickly throughout the body and rapidly gets worse. Of the nine different muscular disorders, Duchenne muscular dystrophy is the most prevalent form found in people today (MDA, 2014).
Duchenne muscular dystrophy affects
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In very rare cases, the daughters may start to show symptoms. If the father had Duchenne muscular dystrophy, he would not be able to pass the disorder on to any of his sons. It is impossible for a son to get the disorder from his father because he receives only the “Y” chromosome from his father which is necessary to make him a male. Duchenne muscular dystrophy is a mutation found on the “X” chromosome so males can only receive the disorder from their mother. Since the father is forced to pass down his “X” chromosome to any females, there is a 100% chance that every daughter will be a carrier of the disorder because the “X” chromosome contains the mutation (MDA,2014). Duchenne muscular dystrophy is a genetic disorder and is normally passed down from one generation to the next; however, it is still possible for a son to be born with Duchenne muscular dystrophy when there was no family history of the disorder. There are two explanations for why this can occur. First, the mutation that leads to Duchenne muscular dystrophy may have existed in the females of the family for some generations without them knowing. They may not have known about the disorder because the affected “X” chromosome was not given to any of the males in the earlier generations, or maybe the relatives in the past generations were not aware of the disease’s presence. Second, a male